Avodart Dutasteride Pharmaceutical Raw Materials for Hair Loss
Alias: Avodart ; Duagen
CAS NO: 164656-23-9
Melting range: 246℃~248℃
Storage: -20°C Freezer
Appearance: white powder.
1, Used in the treatment of benign prostatic hyperplasia. Dual
inhibitor of 5a-reductase isoenzymes type 1 and 2; structurally
related to Finasteride.
2, antihypertensive, ACE inhibitor
3, Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type
1 and 2; structurally related to Finasteride (F342000). Dutasteride
is used in the treatment of benign prostatic hyperplasia.
Dutasteride (trademark name Avodart) is a dual 5-α reductase
inhibitor that inhibits conversion of testosterone to
dihydrotestosterone (DHT). Used for benign prostatic hyperplasia;
however, it increases the risk of erectile dysfunction and
decreased sexual desire.
Dutasteride useful for the symptoms of benign prostatic hyperplasia
(BPH); colloquially known as an "enlarged prostate". In those who
are being regularly screened 5-alpha-reductase inhibitor
(finasteride and dutasteride) reduce the overall risk of being
diagnosed with prostate cancer however there is insufficient data
to determine if they have an effect on the risk of death and may
increase the chance of more serious cases. This class of
medications increases rates of erectile dysfunction (with between
5% and 9% developing problems after starting their use). This is
linked to lower quality of life and can cause stress in
relationships. There is also an association with lowered sexual
desire. It has been reported that these adverse sexual side effects
may persist even after discontinuation of the drug. The FDA has
added a warning to dutasteride about an increased risk of
high-grade prostate cancer. While the potential for positive,
negative or neutral changes to the potential risk of developing
prostate cancer with dutasteride has not been established, evidence
has suggested it may temporarily reduce the growth and prevalence
of benign prostate tumors, but could also mask the early detection
of prostate cancer. The primary area for concern is for patients
who may develop prostate cancer whilst taking dutasteride for
benign prostatic hyperplasia, which in turn could delay diagnosis
and early treatment of the prostate cancer, thereby potentially
increasing the risk of these patients developing high-grade
1). Treating symptoms of benign prostatic hyperplasia (BPH) or
enlargement of the prostate gland. It also helps to reduce the risk
of urinary blockage and the need for surgery to treat BPH. It may
be used alone or along with another medicine (tamsulosin).
Dutasteride is a 5 alpha-reductase enzyme inhibitor. It works by
lowering levels of a hormone called dihydrotestosterone (DHT),
which is a major cause of prostate growth. Lowering DHT leads to
shrinkage of the enlarged prostate gland.
2). How to use Avodart?
A. At 2.5mgs/day is roughly 1.5x more effective than Finasteride at
B, At treating hair loss (both halting it as well as regrowing it).
In addition, Dutasteride can be used successfully at that same dose
to treat prostate enlargement
3). Do NOT use Avodart if?
A. You are allergic to any ingredient in dutasteride or to another
5 alpha-reductase inhibitor (eg, finasteride)
B. The patient is a woman who is pregnant or may become pregnant
C. The patient is a child.
|Product name||Dutasteride (Avodart)|
|Appearance||White crystalline powder|
|Identification||By UV, To match with working standard||Complies|
|Related Substances||Not more than the reference solution (0.05%)||Complies|
|Loss on drying||＜0.5%||0.2%|
|Resiue on ignition||≤0.1%||0.05%|